Understanding Weight Loss Injections and Progesterone in HRT: What You Need to Know

If you’re using weight loss injections like semaglutide (Wegovy or Ozempic) or tirzepatide (Mounjaro) and also taking progesterone as part of your hormone replacement therapy (HRT), it’s important to understand how these treatments may interact.

How They Work:

• Weight loss injections help control appetite and slow stomach emptying, which can lead to reduced food intake and weight loss.

• Progesterone, commonly used in HRT for women with a uterus, helps protect against the risks of oestrogen therapy alone, especially for the uterus lining.

Possible Interaction:

Because weight loss injections slow down how your stomach processes food and medication, they may also affect how oral progesterone is absorbed. This could reduce its effectiveness or cause variations in how your body responds to it.

If you are using weight loss injections and have any worries or concerns about this, please submit a PATCHS request to get personalised advice from a clinician.